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The ZMYND8-regulated mevalonate pathway endows YAP-high intestinal cancer with metabolic vulnerability

Qiang Pan1, Shanshan Zhong2, Hanling Wang1

  • 1CAS Key Laboratory of Tissue Microenvironment and Tumor, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Nutrition and Health, Shanghai Jiao Tong University School of Medicine (SJTUSM) & Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China.

Molecular Cell
|May 1, 2021
PubMed

Keywords:
Colorectal cancerEnhancer-promoter contactIntestinal stem cell (ISC)Mevalonate (MVA) pathwayYAPZMYND8

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