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Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Published on: August 4, 2019

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Tumor suppressor p53: Biology, signaling pathways, and therapeutic targeting

Liz J Hernández Borrero1, Wafik S El-Deiry1

  • 1Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Warren Alpert Medical School, Brown University, Providence, RI 02912, United States of America; Department of Pathology and Laboratory Medicine, Warren Alpert Medical School, Brown University, Providence, RI 02912, United States of America; The Joint Program in Cancer Biology, Brown University and Lifespan Health System, Providence, RI 02912, United States of America; Cancer Center at Brown University, Warren Alpert Medical School, Brown University, Providence, RI 02912, United States of America.

Biochimica Et Biophysica Acta. Reviews on Cancer
|May 1, 2021
PubMed

Insights

The TP53 gene is crucial in cancer, acting as a tumor suppressor. Research is advancing our understanding of its complex pathway and exploring therapeutic strategies for mutant TP53 in oncology.

Area of Science:

  • Oncology
  • Cancer Biology
  • Molecular Biology

Background:

  • The TP53 gene is the most frequently mutated gene in human cancers.
  • The p53 pathway is a critical cellular stress response network involved in tumor suppression.
  • Despite extensive research, clinical translation of p53 pathway knowledge remains challenging.

Purpose of the Study:

  • To review current knowledge on the biology and signaling mechanisms of the p53 pathway.
  • To summarize recent advances in therapeutic development targeting the p53 pathway.
  • To highlight the complexities and challenges in the clinical application of p53 research.

Main Methods:

  • Literature review of TP53 research.
  • Analysis of p53 pathway signaling and its components.
  • Summary of therapeutic strategies targeting wild-type and mutant p53.

Main Results:

  • The p53 pathway is a complex network with diverse inputs and outputs.
  • Mutant TP53 has recognized prognostic value in cancer.
  • Therapeutic modulation of p53 (wild-type and mutant) is an ongoing area of development.

Conclusions:

  • Understanding the p53 pathway is vital for cancer biology and oncology.
  • Further research is needed to overcome clinical translation challenges for p53-targeted therapies.
  • Advances in understanding p53 biology are paving the way for novel therapeutic approaches.
Keywords:
ApoptosisCDKN1ACancerCell cycleDR5PumaTherapeuticsmiRNAp53

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