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GRAMD1-mediated accessible cholesterol sensing and transport

Tomoki Naito1, Yasunori Saheki2

  • 1Lee Kong Chian School of Medicine, Nanyang Technological University, 308232, Singapore.

Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids
|May 1, 2021
PubMed
Summary

Cells use GRAMD1 proteins to sense plasma membrane cholesterol levels and transport it to the ER, maintaining cellular cholesterol homeostasis.

Keywords:
CholesterolGRAM domainMembrane contact sitesNon-vesicular lipid transportPhosphatidylserineStART-like domain

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