The cancer therapy materialization by theranostic nanoparticles based on gold doped iron oxide under electromagnetic...

The harnessing of the cancer X-ray radiation therapy by gold-decorated Fe₃O₄ theranostic nanoparticles (Au-Fe₃O₄ NPs) under electromagnetic field was articulated. The applied electromagnetic field could assemble the NPs inside cell in oriented field direction and enhance the local irradiation dose inside cell. By materializing NPs, the absorption of the energy exposed by X-ray radiation under electromagnetic field was restricted. The cytotoxic properties of the Au-Fe₃O₄ NPs were assessed using MTT assay in L929, HeLa and PC3 cell lines under radiation and dark conditions. The efficiency of the Au-Fe₃O₄ NPs under 2 Gy dose radiations was higher than 6 Gy radiations in untreated cells. The in vitro measurements showed that under electromagnetic field and X-ray radiation therapy with Au-Fe₃O₄ NPs, around 90% of the cancer cells population was annihilated. The in vivo measurements indicated that the tumor shape and size under X-ray with Au-Fe₃O₄ NPs after 3 weeks were efficiently deteriorated.