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Updated: Nov 7, 2025

Induction and Assessment of Exertional Skeletal Muscle Damage in Humans
Published on: December 11, 2016
Moderate intensity cycling is better than running on recovery of eccentric exercise-induced muscle damage
Rodrigo de Azevedo Franke1, Rodrigo Rodrigues2, Jeam Marcel Geremia1
1Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
Objective:
To compare the effects of moderate intensity running and cycling on markers of exercise-induced muscle damage in men.
Study Design:
Randomized controlled trial.
Setting:
Laboratory.
Participants:
Thirty volunteers were randomized in three groups [running (RG; n = 10), cycling (CG; n = 10) and control (CON; n = 10)] and were evaluated at baseline, post 24, 48 and 72 h of knee extensors' muscle damage protocol. CON performed passive recovery, while RG and CG performed active recovery immediately after the protocol, as well as 24 h and 48 h afterwards.
Main Outcomes:
(i) maximal voluntary isometric contraction (MVIC); (ii) delayed-onset muscle soreness (DOMS); (iii) plasma creatine kinase (CK) and lactate dehydrogenase (LDH) levels.
Results:
No group-by-time interaction was found in any outcome evaluated (p > 0.05). All groups presented decreases in MVIC and increases in DOMS (p < 0.001), without differences in CK and LDH. Compared with CON, exercise groups presented likely beneficial effects for LDH, while only CG had a likely beneficial effect for DOMS. Lastly, CG presented likely/very likely beneficial effects for MVIC and DOMS compared to RG.
Conclusion:
Although the null hypothesis analysis did not find differences, the magnitude-based inference analysis suggested that moderate intensity cycling have likely beneficial effects on knee extensor muscle recovery after eccentric exercise protocol.
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