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Diversity of Fusarium species causing invasive and disseminated infections

Priscila Dallé da Rosa1, Valério Aquino2, Alexandre Meneghello Fuentefria3

  • 1Programa de Pós-graduação em Medicina: Ciências Médicas, Universidade Federal do Rio Grande do Sul, Brazil; Experimental Research Center, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Journal De Mycologie Medicale
|May 1, 2021
PubMed
Abstract

Insights

Invasive fusariosis is a growing concern, particularly in immunocompromised patients. This study identified Fusarium solani species complex (FSSC) and FSSC-2h as the most common causes, highlighting the need for molecular identification in diagnostics.

Area of Science:

  • Medical Mycology
  • Fungal Pathogenesis
  • Molecular Diagnostics

Background:

  • Invasive fusariosis (IF) is an emerging global health issue, primarily affecting immunocompromised individuals.
  • Understanding the genetic diversity of Fusarium species causing IF is crucial for effective management.

Purpose of the Study:

  • To molecularly and morphologically characterize Fusarium species from patients with invasive fusariosis.
  • To identify prevalent species and haplotypes associated with IF.

Main Methods:

  • Multilocus sequence typing using RNA polymerase gene (RPB2) and elongation factor 1 alpha (EF-1α).
  • Detailed morphological characterization by experienced mycologists.

Main Results:

  • Fusarium solani species complex (FSSC) and Fusarium oxysporum species complex (FOSC) were the most frequently isolated species.
  • FSSC-2h, FSSC-1, and FOSC-183 were the most common haplotypes.
  • Significant morphological variation was observed in FSSC colonies, while FOSC colonies were more uniform.

Conclusions:

  • FSSC and the FSSC-2h haplotype were predominant in invasive fusariosis cases.
  • Morphological identification alone is insufficient; molecular techniques are essential for accurate Fusarium species identification.
  • Molecular methods should be integrated into routine mycology laboratory practices.
Keywords:
FusariumGenotypingMLSTMolecular diversityMorphology

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