Associative memory improvement after 5 days of magnetic stimulation: A replication experiment with active controls

Associative memory (AM) is an essential function of everyday life, but is often disrupted in many neurological diseases. Recent studies have found that repetitive transcranial magnetic stimulation (rTMS) can effectively enhance AM and have shown its potential in clinical applications. In this study, we aimed to reproduce the 5-day rTMS effect on AM in a Chinese version of a face-cued word recall task. In an open-label experiment, AM scores were significantly improved after active 20-Hz rTMS on individualized inferior parietal lobule (IPL) targets. To exclude the placebo effect, we performed a second experiment and added rTMS of the pre-supplementary motor area (preSMA) as an active control. In this within-subject crossover experiment, participants received active rTMS on IPL and preSMA targets, separated by at least 2 weeks. A Stroop task was included as a control test, which was more likely to be modulated by preSMA stimulations. We found that stimulations on IPL targets significantly improved AM, but this change did not significantly higher than that induced by preSMA stimulations. No significant change in Stroop measures were found in either IPL or preSMA condition. In summary, this study did not support that the 5 days of rTMS on individualized IPL targets could improve AM more than placebo rTMS. Further work is required to improve the rTMS paradigms to enhance the aftereffects in memory.