Phase angle association with metabolic profile in adults: A population-based study

Area of Science:

• Biomarkers
• Metabolic Health
• Human Physiology

Background:

• The phase angle (PhA) is a measure derived from bioelectrical impedance analysis.
• Metabolic syndrome is a cluster of conditions that increase the risk of heart disease, stroke, and type 2 diabetes.
• Understanding biomarkers for cardiometabolic risk is crucial for public health.

Purpose of the Study:

• To investigate the association between phase angle (PhA) and various metabolic profile components in adults.
• To determine if PhA can serve as a potential biomarker for cardiometabolic risk.

Main Methods:

• Cross-sectional, population-based study of 949 adults aged 20-59.
• Phase angle (PhA) measured using electrical bioimpedance analysis.
• Metabolic profile included waist circumference, glucose, lipids, CRP, HOMA-IR, uric acid, and blood pressure; analyzed using linear regression.

Main Results:

• Increased waist circumference was significantly associated with lower phase angle (PhA) values (β: -0.01; 95% CI: -0.03 to -0.01).
• No significant association was found between PhA and glucose, non-HDL-C, triglycerides, CRP, HOMA-IR, or uric acid in adjusted models.

Conclusions:

• Low phase angle (PhA) is directly associated with increased waist circumference in adults, independent of sociodemographic, lifestyle, and BMI adjustments.
• Phase angle (PhA) shows promise as a valuable biomarker for assessing cardiometabolic health in adults.