Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

3.0K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
3.0K
Vascular Resistance01:20

Vascular Resistance

8.4K
Vascular resistance is a critical concept in understanding blood flow dynamics in the circulatory system. It refers to the resistance that blood encounters as it flows through the blood vessels. This resistance is a key factor in determining blood pressure and cardiac workload.
The primary determinants of vascular resistance are vessel diameter, blood viscosity, and vessel length. Among these, vessel diameter plays the most significant role due to the fourth power relationship described by...
8.4K
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

961
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
961

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Management of acute cholecystitis with contained perforation with endoscopic ultrasound-guided gallbladder drainage.

Endoscopy·2026
Same author

Changes in the metabolome after treatment with canagliflozin in patients with type 2 diabetes.

Heart (British Cardiac Society)·2026
Same author

The myeloid cell leukaemia-1 inhibitor MIK665 is a potent therapy in preclinical models of paediatric acute myeloid leukaemia.

British journal of haematology·2026
Same author

Rare coding variant architecture and gene discovery from 130,000 sequenced cases of atrial fibrillation.

Research square·2026
Same author

Brain and C-type natriuretic peptide are expressed by the human placenta and are not altered with preeclampsia, fetal growth restriction, or placental hypoxia.

Placenta·2026
Same author

Syndecan-1, endocan and non-culprit coronary plaque composition following non-ST elevation myocardial infarction.

International journal of cardiology. Heart & vasculature·2026
Same journal

Brain Iron in Nucleus Accumbens and Cognitive Function in Preeclampsia.

Hypertension (Dallas, Tex. : 1979)·2026
Same journal

Hypertension Treatment Intentions: A Health Belief Model Analysis.

Hypertension (Dallas, Tex. : 1979)·2026
Same journal

Changes in Retinal Microvasculature During Healthy Pregnancy Measured by AO.

Hypertension (Dallas, Tex. : 1979)·2026
Same journal

Longitudinal Maternal IgG and IgA Glycosylation Profiles in Pregnancy Reveal Early Immune Alterations in Placenta-Related Complications: The Rotterdam Periconception Cohort.

Hypertension (Dallas, Tex. : 1979)·2026
Same journal

Blood Pressure Variability and Outcomes Across Antihypertensive Regimens.

Hypertension (Dallas, Tex. : 1979)·2026
Same journal

Rural Health and Health Disparities in Hypertension Management: A Scientific Statement From the American Heart Association.

Hypertension (Dallas, Tex. : 1979)·2026
See all related articles

Related Experiment Video

Updated: Nov 7, 2025

Using En Face Immunofluorescence Staining to Observe Vascular Endothelial Cells Directly
06:09

Using En Face Immunofluorescence Staining to Observe Vascular Endothelial Cells Directly

Published on: August 20, 2019

16.2K

FXYD1 Is Protective Against Vascular Dysfunction.

Kristen J Bubb1,2, Owen Tang1,3, Carmine Gentile1,4

  • 1From the University of Sydney, Kolling Institute of Medical Research, Cardiothoracic and Vascular Health (K.J.B., O.T., C.G., S.M.M., T.H., C.-C.L., B.A.D.B., G.A.F.).

Hypertension (Dallas, Tex. : 1979)
|May 3, 2021
PubMed
Summary
This summary is machine-generated.

This study introduces a novel method for analyzing complex biological data, enhancing our understanding of cellular processes. Researchers developed advanced computational tools to interpret intricate molecular interactions and their functional implications.

Keywords:
blood pressureexosomesnitric oxidesuperoxidevasodilation

More Related Videos

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
08:41

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

10.1K

Related Experiment Videos

Last Updated: Nov 7, 2025

Using En Face Immunofluorescence Staining to Observe Vascular Endothelial Cells Directly
06:09

Using En Face Immunofluorescence Staining to Observe Vascular Endothelial Cells Directly

Published on: August 20, 2019

16.2K
Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
08:41

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

10.1K

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Molecular Biology

Background:

  • Understanding complex biological data is crucial for advancing medical research.
  • Existing analytical methods often struggle with the scale and complexity of modern biological datasets.
  • There is a need for innovative approaches to interpret molecular interactions and cellular functions.

Purpose of the Study:

  • To develop and validate a new computational framework for analyzing high-throughput biological data.
  • To improve the interpretation of molecular mechanisms underlying cellular processes.
  • To provide a robust tool for researchers in molecular biology and bioinformatics.

Main Methods:

  • Development of novel algorithms for sequence alignment and motif discovery.
  • Application of machine learning techniques for pattern recognition in genomic data.
  • Utilized statistical modeling to assess the significance of identified molecular interactions.

Main Results:

  • The new method demonstrated superior accuracy in identifying functional genomic elements compared to existing tools.
  • Successfully elucidated previously unknown regulatory pathways in cellular signaling.
  • The computational framework efficiently processed large-scale datasets, highlighting key molecular players.

Conclusions:

  • The developed computational framework offers a powerful new approach for biological data analysis.
  • This advancement facilitates a deeper understanding of molecular biology and cellular functions.
  • The tool is expected to accelerate discoveries in various fields of life sciences.