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Related Experiment Video

Updated: Nov 7, 2025

A Non-invasive Way to Isolate and Phenotype Cells from the Conjunctiva

A Non-invasive Way to Isolate and Phenotype Cells from the Conjunctiva

Published on: July 5, 2017

Corneal biomechanical changes in allergic conjunctivitis.

Qian Wang¹, Yuqing Deng¹, Saiqun Li¹

¹State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, Guangdong, China.

Eye and Vision (London, England)

|May 3, 2021

Summary

This summary is machine-generated.

Allergic conjunctivitis (AC) patients show altered corneal biomechanics and thinner epithelial thickness, increasing keratoconus (KC) risk. Tomography and biomechanical index (TBI) can indicate KC development risk in AC patients.

Keywords:

Allergic conjunctivitis Corneal biomechanics Corneal densitometry Corneal epithelial thickness mapping Corneal tomography

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Published on: November 22, 2024

Area of Science:

Ophthalmology
Corneal Science
Biomechanical Engineering

Background:

Allergic conjunctivitis (AC) is associated with potential ocular changes.
Understanding corneal biomechanical alterations in AC is crucial for early disease detection.
Keratoconus (KC) development risk factors in AC patients require further investigation.

Purpose of the Study:

To investigate corneal biomechanical changes in patients with allergic conjunctivitis (AC).
To identify factors associated with these biomechanical changes.
To determine early indicators for keratoconus (KC) development risk in AC patients.

Main Methods:

Corneal tomography, biomechanics, and epithelial thickness were evaluated in 50 patients (30 with AC, 20 without).
Corneal imaging utilized Pentacam, Corvis ST, and RTvue OCT.
Clinical manifestations of AC, eye rubbing, and allergic sign scores were recorded.

Main Results:

AC patients exhibited significantly higher keratoconus index (KI) and tomography and biomechanical index (TBI) values.
Corneal epithelial thickness was significantly reduced in AC patients.
Higher ISV, IVA, KI, IHD, and BAD-D correlated with TBI and epithelial thickness changes, which were linked to eye rubbing and allergy severity.

Conclusions:

AC patients demonstrate altered corneal tomography and biomechanics.
Routine corneal measurements are recommended for AC patients.
The tomography and biomechanical index (TBI) may serve as an early indicator of KC risk in AC patients.