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Elucidation of host-virus surfaceome interactions using spatial proteotyping.

Fabian Wendt1, Emanuela S Milani1, Bernd Wollscheid1

  • 1Department of Health Sciences and Technology (D-HEST), ETH Zurich, Institute of Translational Medicine (ITM), Zurich, Switzerland; Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland.

Advances in Virus Research
|May 3, 2021
PubMed
Summary

This review explores how cell surface proteins interact with viruses throughout infection. Advanced spatial proteotyping reveals insights for developing new antiviral therapies.

Keywords:
Cell surface proteinsChemoproteomicsDynamic molecular interactionsEntry receptorsHost-pathogen interactionsInfectionProximity mappingSpatial proteotypeSurfaceomeViruses

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Area of Science:

  • Molecular biology
  • Virology
  • Cell biology

Background:

  • The cell surfaceome, comprising extracellular proteins, is crucial for viral infection.
  • Viral propagation relies on dynamic interactions between viruses and the host cell surface.
  • Understanding these interactions is key to developing antiviral strategies.

Purpose of the Study:

  • To review recent experimental strategies for studying viral-host surfaceome interactions.
  • To highlight the role of spatial proteotyping technologies.
  • To inform the design of theranostic approaches against viral infections.

Main Methods:

  • Focus on advanced experimental strategies.
  • Emphasis on spatial proteotyping technologies.
  • Review of literature on viral-host surfaceome interactions.

Main Results:

  • Recent technologies enable detailed decoding of viral-host surfaceome interactions.
  • These insights advance understanding of cellular and viral biology.
  • Identification of key molecular players in viral infection cycles.

Conclusions:

  • Spatial proteotyping offers powerful tools for dissecting viral-host surfaceome dynamics.
  • Understanding these interactions is fundamental for combating viral infections.
  • This knowledge facilitates the rational design of novel theranostic strategies.