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Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...

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Related Experiment Video

Updated: Nov 7, 2025

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia

Published on: June 26, 2020

Stem Cell-Based Therapy for Experimental Ischemic Stroke: A Preclinical Systematic Review.

Xi-Le Zhang¹, Xiao-Guang Zhang¹, Yan-Ran Huang¹

¹Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Frontiers in Cellular Neuroscience

|May 3, 2021

Summary

Stem cell therapy shows promise for ischemic stroke treatment, significantly improving neurological function and reducing infarct volume in animal models. Further clinical research is essential to confirm these neuroprotective effects in humans.

Keywords:

ischemic stroke middle cerebral artery occlusion neuroprotection pre-clinical systematic review stem cell-based therapy

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Last Updated: Nov 7, 2025

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Published on: June 26, 2020

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Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke

Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke

Published on: January 3, 2025

Area of Science:

Neuroscience
Regenerative Medicine
Translational Research

Background:

Ischemic stroke remains a leading cause of disability worldwide.
Stem cell transplantation is a potential therapeutic strategy for stroke recovery.
Understanding the biological effects of stem cells in preclinical models is crucial.

Purpose of the Study:

To systematically review and meta-analyze the efficacy of stem cell transplantation in animal models of ischemic stroke.
To evaluate the impact of stem cell therapy on neurological function and infarct volume.
To identify potential neuroprotective mechanisms and guide future clinical applications.

Main Methods:

Systematic review and meta-analysis of eligible publications from PubMed, EMBASE, and Web of Science.
Inclusion of 98 publications with 141 comparisons and 5,200 animals.
Meta-regression analysis to explore influencing factors.

Main Results:

Stem cell therapy significantly improved neurological function (effect size: -3.37; 95% CI: -3.83 to -2.90).
Stem cell therapy significantly reduced infarct volume (effect size: -11.37; 95% CI: -12.89 to -9.85).
Consistent positive effects observed across various stem cell types and models.

Conclusions:

Stem cell transplantation demonstrates significant neuroprotective effects in experimental ischemic stroke.
Therapeutic benefits include improved neurological function and reduced brain lesion size.
While promising, further clinical trials are necessary to validate these findings in human stroke patients.