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Neutron dose effect relationships at low doses.

J A Dennis¹, L A Dennis

¹National Radiological Protection Board Chilton, Didcot, Oxon, United Kingdom.

Radiation and Environmental Biophysics

|January 1, 1988

Summary

Re-examining mutation data in Tradescantia occidentalis confirms non-linear dose-effect relationships for radiation, suggesting cell cycle sensitivity and potential differences between neutron and photon radiation biophysics.

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Area of Science:

Radiation biology
Genetics
Cell biology

Background:

Recent observations indicate non-linear dose-effect relationships in mammalian cell transformation by fission neutron irradiation.
A reverse dose rate effect has also been noted in these systems.
These findings prompted a re-examination of mutation induction data in Tradescantia occidentalis.

Purpose of the Study:

To re-examine mutation induction data in Tradescantia occidentalis stamen hairs.
To confirm or refute non-linear dose-effect relationships observed in previous studies.
To explore potential explanations for observed non-linearities and radiation effects.

Main Methods:

Statistical re-analysis of existing mutation induction data from Tradescantia occidentalis.
Examination of dose-effect relationships and their statistical significance.
Comparison with recent observations from other researchers in the field.

Main Results:

The re-examination confirmed non-linear dose-effect relationships in mutation induction.
Statistical analysis supported the presence of these non-linearities.
Non-linearity was also observed in more recent studies by other researchers.

Conclusions:

The non-linear dose-effect relationship in this system is confirmed.
A potential explanation for the non-linearity is the presence of a sub-population of cells in a sensitive cell cycle phase during irradiation.
The data may suggest qualitative differences in the biophysical actions of neutron versus photon radiation.

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