Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hydrogen Bonds01:04

Hydrogen Bonds

11.5K
A hydrogen bond is formed when a weakly positive hydrogen atom already bonded to one electronegative atom (for example, the oxygen in the water molecule) is attracted to another electronegative atom from another polar molecule, such as water (H2O), hydrogen fluoride (HF), or ammonia (NH3). The huge electronegativity difference between the H atom (2.1) and the atom to which it is bonded (4.0 for an F atom, 3.5 for an O atom, or 3.0 for an N atom), combined with the very small size of an H atom...
11.5K
Hydrogen Bonds00:26

Hydrogen Bonds

128.3K
Hydrogen bonds are weak attractions between atoms that have formed other chemical bonds. One of these atoms is electronegative, like oxygen, and has a partial negative charge. The other is a hydrogen atom that has bonded with another electronegative atom and has a partial positive charge.
Hydrogen Bonds Control the World!
Because hydrogen has very weak electronegativity when it binds with a strongly electronegative atom, such as oxygen or nitrogen, electrons in the bond are unequally shared....
128.3K
Introduction to Chemical Bonds01:01

Introduction to Chemical Bonds

10.3K
Chemical Bonds
The electrons of the outermost energy level determine the energetic stability of the atom and its tendency to form chemical bonds with other atoms. The innermost electron shell has a maximum capacity of two electrons, but the next two electron shells can each have a maximum of eight electrons. This is known as the octet rule, which states that, with the exception of the innermost shell, atoms are most stable energetically when they have eight electrons in their valence shell, the...
10.3K
Valence Bond Theory02:45

Valence Bond Theory

41.8K
Overview of Valence Bond Theory
41.8K
Valence Bond Theory02:42

Valence Bond Theory

10.0K
Coordination compounds and complexes exhibit different colors, geometries, and magnetic behavior, depending on the metal atom/ion and ligands from which they are composed. In an attempt to explain the bonding and structure of coordination complexes, Linus Pauling proposed the valence bond theory, or VBT, using the concepts of hybridization and the overlapping of the atomic orbitals. According to VBT, the central metal atom or ion (Lewis acid) hybridizes to provide empty orbitals of suitable...
10.0K
Covalent Bonding and Lewis Structures02:46

Covalent Bonding and Lewis Structures

57.3K
Compared to ionic bonds, which results from the transfer of electrons between metallic and nonmetallic atoms, covalent bonds result from the mutual attraction of atoms for a “shared” pair of electrons.
57.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Topological Control of Paratropicity via Alternative Ring Fusion in Indacenodithiophene Isomers.

The Journal of organic chemistry·2026
Same author

A Persistent Ni(0)-Pentalene Complex with High Fluxionality: Does Stronger Antiaromaticity Promote Metal-Ligand Interactions?

Journal of the American Chemical Society·2026
Same author

Three wrongs make a right: a computational investigation of [4<i>n</i>]-[4<i>n</i>]-[4<i>n</i>] fused π-systems.

Chemical science·2026
Same author

Redox- and Protonation-Tunable Diboraheptacenes.

Journal of the American Chemical Society·2026
Same author

Carbenes Embedded in Cyclic Paraphenylenes: Detection, Ground-State Spin Multiplicity, and Möbius Aromaticity.

Journal of the American Chemical Society·2026
Same author

Synthesis and photoluminescence of iridium(III) arylacetylide complexes with acetylide-localized emissive excited states.

Dalton transactions (Cambridge, England : 2003)·2026

Related Experiment Video

Updated: Nov 7, 2025

From Molecules to Materials: Engineering New Ionic Liquid Crystals Through Halogen Bonding
06:44

From Molecules to Materials: Engineering New Ionic Liquid Crystals Through Halogen Bonding

Published on: March 24, 2018

69.3K

Hydrogen bond design principles.

Lucas J Karas1, Chia-Hua Wu1, Ranjita Das1

  • 1Department of Chemistry, University of Houston, Houston, TX.

Wiley Interdisciplinary Reviews. Computational Molecular Science
|May 3, 2021
PubMed
Summary
This summary is machine-generated.

This study explores how molecular structure influences hydrogen bond strength, detailing electronic effects and historical discoveries. It highlights key principles for designing supramolecular structures using hydrogen bonds.

Keywords:
aromaticityhydrogen bondingresonance-assisted hydrogen bondingsecondary electrostatic interactions

More Related Videos

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates
06:35

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates

Published on: February 15, 2016

8.3K
Probing the Structure and Dynamics of Interfacial Water with Scanning Tunneling Microscopy and Spectroscopy
10:28

Probing the Structure and Dynamics of Interfacial Water with Scanning Tunneling Microscopy and Spectroscopy

Published on: May 27, 2018

9.1K

Related Experiment Videos

Last Updated: Nov 7, 2025

From Molecules to Materials: Engineering New Ionic Liquid Crystals Through Halogen Bonding
06:44

From Molecules to Materials: Engineering New Ionic Liquid Crystals Through Halogen Bonding

Published on: March 24, 2018

69.3K
Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates
06:35

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates

Published on: February 15, 2016

8.3K
Probing the Structure and Dynamics of Interfacial Water with Scanning Tunneling Microscopy and Spectroscopy
10:28

Probing the Structure and Dynamics of Interfacial Water with Scanning Tunneling Microscopy and Spectroscopy

Published on: May 27, 2018

9.1K

Area of Science:

  • Supramolecular Chemistry
  • Chemical Physics

Background:

  • Hydrogen bonding is fundamental to supramolecular chemistry.
  • Understanding hydrogen bond strength is crucial for molecular design.

Purpose of the Study:

  • To review the relationship between molecular structure and hydrogen bond strength.
  • To discuss electronic effects influencing hydrogen bonds.
  • To outline historical developments and applications of hydrogen bond design principles.

Main Methods:

  • Literature review of experimental and computational studies.
  • Analysis of electronic effects (electronegativity, electrostatics, π-conjugation, etc.).
  • Discussion of historical evolution of hydrogen bond concepts.

Main Results:

  • Identified key electronic factors affecting hydrogen bond strength.
  • Detailed nonclassical hydrogen bonds (e.g., C-H…O, O-H…π).
  • Presented design principles like resonance-assisted hydrogen bonding.

Conclusions:

  • Molecular structure dictates hydrogen bond strength.
  • Established principles enable rational supramolecular design.
  • Applications span various chemical and material science fields.