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Retroperitoneal liposarcoma mimicking pheochromocytoma
Fidel Rampersad1, Jason Diljohn2, Surujpal Teelucksingh3
1Radiology Unit, Department of Clinical Medical Sciences, The University of the West Indies, St Augustine Campus, Trinidad, West Indies.
Retroperitoneal liposarcomas can mimic pheochromocytomas, presenting with similar symptoms and biochemical markers. Intralesional fat on imaging is a key differentiator for diagnosing this rare retroperitoneal tumor.
Area of Science:
- Oncology
- Radiology
- Endocrinology
Background:
- Retroperitoneal liposarcomas are rare mesenchymal tumors with poor prognosis due to late presentation.
- Symptoms are often nonspecific, related to mass effect or local invasion.
Observation:
- A 56-year-old female presented with symptoms mimicking pheochromocytoma, including hypertension, sweating, and weakness.
- Imaging revealed a suprarenal mass suspicious for pheochromocytoma, with elevated urinary catecholamines.
Findings:
- Histological analysis confirmed a dedifferentiated retroperitoneal liposarcoma, not a pheochromocytoma.
- Intralesional fat noted on CT and MRI, an atypical feature for pheochromocytoma, suggested liposarcoma.
Implications:
- This case highlights the importance of considering retroperitoneal liposarcoma in the differential diagnosis of suspected pheochromocytoma.
- Presence of intralesional fat on imaging can aid in distinguishing these conditions, despite similar clinical and biochemical presentations.
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