Related Experiment Video
Updated: Nov 7, 2025

10:01
Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
Published on: July 10, 2012
20.7K
Pediatric follicular bronchiolitis with severe atelectasis: a case report
1Department of Thoracic & Cardiovascular Surgery, Daegu Catholic University Hospital, Catholic University of Daegu, College of Medicine South Korea.
Summary
Follicular bronchiolitis, a rare lung condition, was diagnosed in a child with persistent respiratory issues. Treatment with steroids significantly improved her pulmonary function after other therapies failed.
Area of Science:
- Pulmonology
- Pediatric Respiratory Medicine
- Histopathology
Background:
- Follicular bronchiolitis is a rare pulmonary disorder characterized by hyperplastic lymphoid follicles around bronchioles.
- Diagnosis can be challenging due to non-specific clinical and radiological findings.
Observation:
- An 11-year-old girl presented with right middle lobe atelectasis, lung nodules, and recurrent respiratory infections.
- The condition progressed despite macrolide therapy, necessitating thoracoscopic biopsy and right middle lobe lobectomy.
Findings:
- Histopathological examination confirmed follicular bronchiolitis.
- The patient experienced dramatic improvement in pulmonary function following oral steroid treatment.
Implications:
- Follicular bronchiolitis requires histopathological confirmation for accurate diagnosis.
- Lobectomy may be necessary for diagnosis and treatment in cases of irreversible atelectasis and recurrent infections.
Related Concept Videos
Pulmonary Cycle: Exhalation
2.3K
In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
2.3K
Acute Respiratory Failure-II
610
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
610
Acute Respiratory Failure-III
448
Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without...
448
Acute Respiratory Failure-I
508
Acute respiratory failure is a condition characterized by the inability of the lungs to perform their primary function: gas exchange. This failure leads to insufficient oxygen levels (hypoxemia) in the blood, elevated carbon dioxide levels (hypercapnia), or both, causing critical impairment in organ function.
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
508
Acute Respiratory Failure-V
266
The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Ensure that patients are monitored continuously for their response to therapy, including changes in...
266
Pneumonia III: Complications and Assessment
554
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
554

