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Moxifloxacin Monotherapy in Left-Sided Staphylococcus aureus Endocarditis

Yucel Colkesen1

  • 1Department of Cardiology, Erdem Hospital, Istanbul, Turkey.

Case Reports in Infectious Diseases
|May 3, 2021
PubMed

Insights

This case study highlights a successful treatment of Staphylococcus aureus endocarditis using moxifloxacin monotherapy. The findings suggest moxifloxacin as a potential therapeutic option for this serious infection.

Area of Science:

  • Infectious Diseases
  • Cardiology
  • Pharmacology

Background:

  • Staphylococcus aureus is a leading cause of infective endocarditis, a serious condition with high mortality rates.
  • Despite advancements in treatment, mortality for S. aureus endocarditis remains a significant clinical challenge.
  • Native valve endocarditis requires effective antimicrobial strategies.

Observation:

  • An 83-year-old female patient presented with symptoms of fatigue and fever.
  • Transthoracic echocardiography revealed vegetation on the heart valve.
  • Blood cultures confirmed the presence of methicillin-sensitive Staphylococcus aureus.

Findings:

  • The patient received a 14-day course of intravenous moxifloxacin.
  • A subsequent four-week oral moxifloxacin regimen was administered.
  • The patient demonstrated a positive clinical response to moxifloxacin monotherapy.

Implications:

  • Moxifloxacin monotherapy may be an effective treatment option for left-sided native valve endocarditis caused by S. aureus.
  • This case suggests a potential alternative to combination antibiotic therapies.
  • Further research is warranted to evaluate the efficacy and safety of moxifloxacin in a larger patient cohort.

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