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Updated: Nov 7, 2025

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Longitudinal changes on liver proton density fat fraction differ between liver segments.

Jan Syväri1, Daniela Junker1, Lisa Patzelt1

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Quantitative Imaging in Medicine and Surgery
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PubMed
Summary

Liver fat fraction changes unevenly across the liver, with greater changes in the right lobe compared to the left lobe during a one-year lifestyle intervention. This highlights the need for spatial analysis in liver fat studies.

Keywords:
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Area of Science:

  • Medical Imaging
  • Hepatology
  • Metabolic Research

Background:

  • Investigating spatial heterogeneity of liver fat fraction is crucial for understanding metabolic changes.
  • Longitudinal studies require precise methods to track liver fat content over time.

Purpose of the Study:

  • To assess spatial variations in liver fat fraction changes over one year.
  • To compare liver fat changes between liver lobes and segments using MRI.
  • To evaluate the impact of a lifestyle intervention on liver fat distribution.

Main Methods:

  • Utilized magnetic resonance imaging (MRI) for non-invasive liver fat assessment.
  • Employed a chemical shift encoding-based water-fat separation technique.
  • Measured liver proton density fat fraction (PDFF) maps in 32 subjects over a one-year period.

Main Results:

  • The right liver lobe showed a stronger correlation with overall mean liver PDFF changes than the left lobe.
  • Segment VII demonstrated the highest agreement with mean liver PDFF changes, while Segment I showed the lowest.
  • Significant spatial heterogeneity in liver fat fraction changes was observed.

Conclusions:

  • Liver fat fraction changes are not uniform, with greater changes typically occurring in the right lobe.
  • These findings support the existing literature on the heterogeneous spatial distribution of liver fat.
  • Spatially resolved analysis of liver fat fraction is essential for accurate interpretation of longitudinal study data.