The Association Between Intestinal Bacteria and Allergic Diseases-Cause or Consequence?

Area of Science:

• Immunology
• Microbiology
• Genetics

Background:

• Allergic disorder incidence is increasing globally, particularly in industrialized nations.
• Allergic disease pathogenesis is complex, involving genetic, epigenetic, and environmental factors.
• Gut microbiota is increasingly recognized as a significant factor in allergic disease development.

Purpose of the Study:

• To review the association between allergic disorders and intestinal bacterial dysbiosis.
• To describe the role of gut microbes in allergic disease development using preclinical and clinical data.
• To discuss factors influencing gut microbial diversity and advanced analysis techniques.

Main Methods:

• Literature review of preclinical and clinical studies.
• Analysis of factors influencing gut microbial diversity.
• Summary of advanced microbial analysis techniques.

Main Results:

• Evidence links intestinal bacterial dysbiosis to the development of allergic diseases.
• Gut microbes influence allergic disease pathogenesis through various mechanisms.
• Factors affecting gut microbial diversity are crucial in understanding allergy development.

Conclusions:

• Further research is needed to elucidate the host-microbial relationship in allergic disorders.
• Understanding these relationships may lead to novel therapeutic interventions for allergies.
• Targeting the gut microbiome presents a potential avenue for allergy treatment.