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The Genetic Pathways Underlying Immunotherapy in Dilated Cardiomyopathy
Ayat Kadhi1, Fathima Mohammed1, Georges Nemer1,2
1Division of Genomics and Translational Biomedicine, College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar.
Frontiers in Cardiovascular Medicine
|May 3, 2021
Summary
Dilated cardiomyopathy (DCM) causes heart failure and sudden death. This review explores genetic and inflammatory triggers, highlighting precision medicine and immunomodulatory strategies for better heart failure management.
Area of Science:
- Cardiology
- Immunology
- Genetics
Background:
- Heart failure (HF) is a growing global health concern, with Dilated Cardiomyopathy (DCM) being a primary cause of HF and sudden death in all age groups.
- DCM involves ventricular dilation and systolic dysfunction, stemming from genetic factors or secondary causes like myocardial inflammation.
- Despite advancements, DCM's morbidity and mortality rates remain high, necessitating novel therapeutic approaches.
Purpose of the Study:
- To review the genetic and inflammatory underpinnings of DCM.
- To explore novel precision medicine and immunomodulatory strategies for managing DCM-related heart failure.
Main Methods:
- Literature review focusing on genetic and inflammatory etiologies of DCM.
- Analysis of current and emerging precision medicine approaches.
- Examination of immunomodulatory treatment pathways.
Main Results:
- DCM pathogenesis is linked to both genetic predispositions and inflammatory processes.
- Emerging research highlights the interplay between genetic and inflammatory factors in DCM.
- Precision medicine offers targeted treatment strategies based on individual causative factors.
Conclusions:
- Understanding the dual genetic and inflammatory basis of DCM is crucial for effective management.
- Precision medicine and immunomodulatory therapies represent a promising frontier for treating DCM and preventing heart failure.
- Targeted interventions addressing specific etiologies can improve patient outcomes in DCM.
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