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Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.8K
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

2.8K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
2.8K
Asthma-IV: Nursing Management01:30

Asthma-IV: Nursing Management

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The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
First, in...
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Related Experiment Video

Updated: Nov 7, 2025

Nasal Brushing Sampling and Processing Using Digital High Speed Ciliary Videomicroscopy &#8211; Adaptation for the COVID-19 Pandemic
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COVID-19 and bronchial asthma: current perspectives.

Masayuki Hojo1, Junko Terada-Hirashima1, Haruhito Sugiyama1

  • 1Division of Respiratory Medicine, National Center for Global Health and Medicine, Tokyo, Japan.

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Summary

Asthma patients may be less susceptible to COVID-19 due to lower ACE2 receptor expression. Current asthma treatments, including biologics, should continue during the pandemic.

Keywords:
ACE2ICSTMPRSS2biologicscoronavirus disease 2019 (COVID-19)

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Area of Science:

  • Pulmonology
  • Virology
  • Immunology

Background:

  • Angiotensin converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) are key receptors for SARS-CoV-2 entry into bronchial epithelial cells.
  • Increased ACE2 expression in aged, male, and smoking individuals, including those with COPD, correlates with higher SARS-CoV-2 infection risk and COVID-19 severity.
  • Asthma patients exhibit similar or lower ACE2 and TMPRSS2 expression compared to healthy individuals, particularly those with atopy or poor asthma control.

Purpose of the Study:

  • To investigate the susceptibility of asthma patients to COVID-19.
  • To evaluate the role of ACE2 and TMPRSS2 expression in asthma patients regarding SARS-CoV-2 infection.
  • To provide guidance on asthma management during the COVID-19 pandemic.

Main Methods:

  • Review of existing literature on ACE2 and TMPRSS2 expression in respiratory diseases.
  • Epidemiological analysis of COVID-19 incidence and severity in asthma patients.
  • Analysis of trends in asthma exacerbations during the COVID-19 pandemic.

Main Results:

  • Asthma patients appear less susceptible to SARS-CoV-2 infection.
  • Lower ACE2 expression is observed in asthma patients, especially those with atopic factors and poor asthma control.
  • A reduction in asthma exacerbation hospitalizations was noted during the COVID-19 pandemic in Japan.
  • No clear evidence suggests asthma exacerbates COVID-19.

Conclusions:

  • Asthma patients may have a lower risk of contracting COVID-19.
  • Continued regular asthma treatment, including biologics for severe cases, is recommended during the COVID-19 pandemic.
  • Asthma does not appear to be an aggravating factor for COVID-19.