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Related Concept Videos

Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

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Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
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The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
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Interpret with caution: randomized controlled trials comparing cemented versus press-fit hemiarthroplasty in geriatric patients with intracapsular hip fractures are statistically fragile.

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What is the desired screw trajectory for fixation of noncontiguous posterior distal articular fractures associated with distal tibial shaft fractures?

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Related Experiment Video

Updated: Nov 7, 2025

Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury
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Polytrauma: update on basic science and clinical evidence.

Aaron Nauth1, Frank Hildebrand2, Heather Vallier3

  • 1Division of Orthopaedics, Department of Surgery, University of Toronto and St. Michael's Hospital, Toronto, Ontario, Canada.

OTA International : the Open Access Journal of Orthopaedic Trauma
|May 3, 2021
PubMed
Summary
This summary is machine-generated.

Managing severely injured patients requires understanding trauma response and patient status indicators. Timely fracture fixation is crucial for optimal outcomes in polytraumatized individuals.

Keywords:
damage control surgeryearly appropriate careinflammationneutrophilpolytrauma

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Area of Science:

  • Orthopaedic Trauma Surgery
  • Trauma Critical Care

Background:

  • Management of multiply injured patients is complex and dynamic.
  • Fracture fixation is a critical component of multidisciplinary care for trauma patients.
  • Understanding trauma pathophysiology and patient status indicators is essential.

Purpose of the Study:

  • To summarize a symposium on the management of multiply injured patients.
  • To highlight advancements in clinical and basic science research in polytrauma management.
  • To present an expert panel's insights on orthopaedic trauma care.

Main Methods:

  • Summary of a symposium presented at the 2020 Virtual Annual Meeting of the Orthopaedic Trauma Association.
  • Expert panel discussion on polytrauma management.
  • Review of current understanding in trauma pathophysiology and patient status.

Main Results:

  • Progress in clinical and basic science research has advanced the understanding of polytrauma.
  • An expert panel shared insights on the dynamic nature of managing severely injured patients.
  • Emphasis on timely and safe fracture fixation as a key element of care.

Conclusions:

  • Effective management of polytraumatized patients requires a deep understanding of trauma response.
  • Multidisciplinary care, including timely fracture fixation, is vital for optimal patient outcomes.
  • Continued research is advancing the approach to managing complex orthopaedic trauma.