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ROS-Driven selection pressure on COVID-19 patients with cardiovascular comorbidities
Xiaofeng Dai1, Kostya Ken Ostrikov2
1Wuxi School of Medicine, Jiangnan University, Wuxi 214122, China.
Abstract:
Coronavirus disease 2019 (COVID-19) has imposed a global health threat which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Currently available data point out that ACE2, the receptor of SARS-CoV-2 in host cells, does not predispose the risk or severity of COVID-19, but rather elevated levels of reactive oxygen species (ROS) impose abnormal selection pressure on patients having cardiovascular comorbidities. As clinical and preventative practice, ROS scavengers are thus recommended for effective therapeutic control of COVID-19 and cardiovascular diseases.
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