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A Novel Approach to Monitoring Graft Neovascularization in the Human Gingiva
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Primary graft dysfunction.

Rachel N Criner1, Emily Clausen1, Edward Cantu2

  • 1Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania Perelman School of Medicine.

Current Opinion in Organ Transplantation
|May 3, 2021
PubMed
Summary

Primary graft dysfunction (PGD) after lung transplant is a major concern. While new risk factors are identified, effective prevention and treatment strategies for PGD remain critical needs.

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Area of Science:

  • Pulmonology
  • Transplantation Medicine
  • Critical Care

Background:

  • Primary graft dysfunction (PGD) is a severe complication following lung transplantation.
  • It significantly increases short-term mortality and risk of chronic rejection.

Purpose of the Study:

  • To review the definition, pathophysiology, and risk factors of PGD.
  • To discuss current and future prevention and treatment strategies for PGD.
  • To explore emerging research directions in managing PGD.

Main Methods:

  • Review of recent literature on PGD in lung transplantation.
  • Analysis of donor and recipient factors influencing PGD risk.
  • Evaluation of novel therapeutic approaches, including ex vivo lung perfusion (EVLP).

Main Results:

  • Donors after circulatory death and brain death show similar PGD rates; older donors (>55 years) do not increase risk.
  • Recipient factors like diastolic dysfunction and obesity are associated with higher PGD risk.
  • Emerging biomarkers and genetic factors require further clinical validation; EVLP shows promise for prevention.

Conclusions:

  • Significant advancements have been made in defining PGD and identifying risk factors.
  • Effective prevention and treatment strategies for PGD are still urgently needed.
  • Future research should focus on targeted therapies and EVLP for donor lung reconditioning.