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Prevalence and Mortality due to COVID-19 in HIV Co-Infected Population: A Systematic Review and Meta-Analysis

Min Liang1, Ning Luo2, Mafeng Chen3

  • 1Department of Respiratory and Critical Care Medicine, Maoming People's Hospital, Maoming, China. imtuaska@163.com.

Infectious Diseases and Therapy
|May 3, 2021
PubMed

Insights

COVID-19 in people with HIV/AIDS (PLWHA) had a prevalence of 0.774% and mortality of 8.814%. However, COVID-19 co-infected PLWHA did not show higher mortality compared to non-PLWHA.

Area of Science:

  • Infectious Diseases
  • Epidemiology
  • Public Health

Background:

  • COVID-19 pandemic presents a global health crisis.
  • Limited understanding of COVID-19's impact on people living with HIV/AIDS (PLWHA).

Purpose of the Study:

  • To investigate the prevalence and mortality rates of COVID-19 in PLWHA.

Main Methods:

  • Systematic review of studies from PUBMED, EMBASE, BioRxiv, and medRxiv up to March 9, 2021.
  • Included cohort studies and case series focusing on COVID-19 in PLWHA.

Main Results:

  • 14 studies identified, encompassing 203,761 COVID-19 patients (7,718 PLWHA).
  • Estimated COVID-19 prevalence in PLWHA was 0.774% and mortality was 8.814%.
  • No significant difference in mortality risk between COVID-19 co-infected PLWHA and non-PLWHA (RR 0.96). Comorbidities like diabetes, hypertension, and kidney disease increased mortality risk.

Conclusions:

  • COVID-19 prevalence and mortality in PLWHA are estimated at 0.774% and 8.814%, respectively.
  • Comparisons between PLWHA and non-PLWHA should be made cautiously due to unmatched populations in most studies.
  • Further research is needed on factors like CD4 count, viral load, and antiretroviral therapy in relation to COVID-19 outcomes in PLWHA.
Abstract

Keywords:
COVID-19HIVMeta-analysisPrevalencePrognosisSystematic review

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