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Related Experiment Video

Updated: Nov 7, 2025

Assessing Teratogenic Changes in a Zebrafish Model of Fetal Alcohol Exposure
10:07

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Embryonic ethanol exposure on zebrafish early development.

Jaquelinne Pinheiro-da-Silva1, Ana Carolina Luchiari1

  • 1Physiology and Behavior Department, Federal University of Rio Grande do Norte, Natal, Brazil.

Brain and Behavior
|May 3, 2021
PubMed
Summary
This summary is machine-generated.

Ethanol exposure during zebrafish embryogenesis causes physical and developmental harm. This study reinforces zebrafish as a valuable model for understanding fetal alcohol spectrum disorders (FASD).

Keywords:
alcoholembryogenesismorphology

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Area of Science:

  • Developmental Biology
  • Toxicology
  • Neuroscience

Background:

  • Fetal alcohol spectrum disorders (FASD) encompass physical, behavioral, and cognitive deficits.
  • Zebrafish are increasingly utilized as a model organism for studying FASD and its variations.

Purpose of the Study:

  • To characterize zebrafish embryonic and larval development following exposure to varying ethanol concentrations.
  • To assess the impact of ethanol on key developmental parameters in zebrafish.

Main Methods:

  • Zebrafish embryos were exposed to 0.0%, 0.25%, 0.5%, and 1.0% ethanol at 24 hours postfertilization.
  • Developmental observations included movement, phenotypic abnormalities, hatching, cardiac function, larval length, and apoptosis.
  • Acridine orange staining was used to quantify apoptotic cells.

Main Results:

  • Exposure to 0.5% and 1.0% ethanol resulted in reduced body size and decreased heartbeat rate.
  • Increased numbers of apoptotic cells and altered hatching times were observed with higher ethanol concentrations.
  • Ethanol exposure negatively impacted embryonic and larval development.

Conclusions:

  • Even low to moderate ethanol exposure during embryogenesis can be detrimental.
  • Zebrafish serve as a suitable and effective model for investigating the developmental impacts of ethanol, relevant to FASD research.