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Smoking Is Associated With Basal Cell Hyperplasia on Prostate Biopsy Specimens
Daniel Melecchi Freitas1,2, Gerald L Andriole3, Stephen J Freedland4,5
1Division of Urology, Nossa Senhora da Conceição Hospital, Porto Alegre, Brazil.
American Journal of Clinical Pathology
|May 3, 2021
Summary
Current cigarette smoking is linked to a higher occurrence of basal cell hyperplasia (BCH) in men undergoing prostate biopsies. This association remained significant after adjusting for other patient factors, highlighting smoking as a potential risk for prostate cell changes.
Area of Science:
- Urology
- Oncology
- Public Health
Background:
- Prostate basal cell hyperplasia (BCH) is a common finding in prostate biopsies.
- The association between cigarette smoking and prostate basal cell proliferation has not been previously studied.
Purpose of the Study:
- To investigate the relationship between smoking status and the presence of basal cell hyperplasia (BCH) in men.
- To determine if current smoking is independently associated with BCH.
Main Methods:
- Retrospective analysis of 8,196 men aged 50-75 from the REDUCE trial.
- Smoking status categorized as current, former, or never smokers.
- Logistic regression used to assess the association between smoking and baseline BCH.
Main Results:
- Current smokers had a significantly higher incidence of BCH compared to never smokers (OR, 1.92) and former smokers (OR, 1.71) after multivariable adjustment.
- The study included men with PSA levels between 2.5-10 µg/mL and prior negative biopsies.
Conclusions:
- Current cigarette smoking is independently associated with basal cell hyperplasia (BCH) in men with negative prostate biopsy results.
- Findings suggest smoking may contribute to prostate basal cell changes.
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