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Related Concept Videos

Aging01:26

Aging

385
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
385
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

59
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
59
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

49
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
49
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

66
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
66
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

50
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
50
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

42
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
42

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Geriatrics: Moving forward with 2020 vision.

Sonia G Pandit1, Lisa M Walke1

  • 1Department of Medicine, Division of Geriatric Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Journal of the American Geriatrics Society
|May 3, 2021
PubMed
Summary
This summary is machine-generated.

The year 2020 offered Geriatric Medicine opportunities to advance whole-person care. Key lessons include enhanced marketing, patient advocacy, strategic partnerships, addressing injustice, and expanding care scope to ensure the specialty remains mainstream.

Keywords:
Geriatricsadvocacymarketing

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Area of Science:

  • Geriatric Medicine
  • Healthcare Policy
  • Public Health

Background:

  • Geriatric Medicine faces ongoing debates regarding its specialty parameters and positioning.
  • The year 2020 presented unique challenges and opportunities for Geriatric Medicine.
  • Major events in 2020 included the COVID-19 pandemic, the Racial Justice Movement, and elections.

Purpose of the Study:

  • To reflect on the new perspectives, programs, and partnerships initiated in 2020 within Geriatric Medicine.
  • To identify key lessons that can help safeguard the future of Geriatrics.
  • To explore how Geriatric Medicine can maintain and strengthen its mainstream position.

Main Methods:

  • Qualitative reflection on the events of 2020 and their impact on Geriatric Medicine.
  • Analysis of emerging trends and opportunities within the specialty.
  • Identification of five broader lessons for the future of Geriatrics.

Main Results:

  • Five lessons emerged for safeguarding Geriatrics: direct-to-consumer marketing, expanded patient advocacy, new strategic partnerships, addressing racial injustice, and leveraging skillsets for expanded care.
  • The interdisciplinary nature of Geriatrics facilitates collaborative approaches.
  • Lessons derived from outside healthcare can benefit the field.

Conclusions:

  • The events of 2020 provided Geriatric Medicine with "2020 vision" to remain mainstream.
  • Geriatrics has renewed promise as specialists in whole-person care.
  • Implementing these lessons can help the specialty achieve its vision in the current decade and beyond.