Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

5.7K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
5.7K
Metastasis02:30

Metastasis

6.0K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
6.0K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

9.3K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enhancing risk stratification and treatment decision in multiple myeloma with SKY92 gene expression profiling in real-world data.

British journal of haematology·2025
Same author

Combinatorial Analysis of miRNAs and tRNA Fragments as Potential Biomarkers for Cancer Patients in Liquid Biopsies.

Non-coding RNA·2025
Same author

Full-length tRNAs lacking a functional CCA tail are selectively sorted into the lumen of extracellular vesicles.

bioRxiv : the preprint server for biology·2024
Same author

Global and single-nucleotide resolution detection of 7-methylguanosine in RNA.

RNA biology·2024
Same author

Assessing the complementary information from an increased number of biologically relevant features in liquid biopsy-derived RNA-Seq data.

Heliyon·2024
Same author

The immunological landscape of peripheral blood in glioblastoma patients and immunological consequences of age and dexamethasone treatment.

Frontiers in immunology·2024

Related Experiment Video

Updated: Nov 7, 2025

Combined Use of Tail Vein Metastasis Assays and Real-Time In Vivo Imaging to Quantify Breast Cancer Metastatic Colonization and Burden in the Lungs
10:32

Combined Use of Tail Vein Metastasis Assays and Real-Time In Vivo Imaging to Quantify Breast Cancer Metastatic Colonization and Burden in the Lungs

Published on: December 19, 2019

11.2K

Platelets and tumor-associated RNA transfer.

Silvia D'Ambrosi1, R Jonas Nilsson2, Thomas Wurdinger1

  • 1Department of Neurosurgery, Amsterdam UMC, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, The Netherlands; and.

Blood
|May 3, 2021
PubMed
Summary
This summary is machine-generated.

Cancer cells can alter platelet RNA content, creating "tumor-educated platelets." These RNA profiles show promise as biomarkers for early cancer detection and monitoring treatment effectiveness.

Keywords:
PLATELETS/Platelet interactions with other cellsPlateletsRNAcancerdiagnosticsliquid biopsy

More Related Videos

Identification and Characterization of Metastatic Factors by Gene Transfer into the Novel RIP-Tag; RIP-tva Murine Model
09:03

Identification and Characterization of Metastatic Factors by Gene Transfer into the Novel RIP-Tag; RIP-tva Murine Model

Published on: October 16, 2017

8.9K
Real-time Imaging of Heterotypic Platelet-neutrophil Interactions on the Activated Endothelium During Vascular Inflammation and Thrombus Formation in Live Mice
11:18

Real-time Imaging of Heterotypic Platelet-neutrophil Interactions on the Activated Endothelium During Vascular Inflammation and Thrombus Formation in Live Mice

Published on: April 2, 2013

15.9K

Related Experiment Videos

Last Updated: Nov 7, 2025

Combined Use of Tail Vein Metastasis Assays and Real-Time In Vivo Imaging to Quantify Breast Cancer Metastatic Colonization and Burden in the Lungs
10:32

Combined Use of Tail Vein Metastasis Assays and Real-Time In Vivo Imaging to Quantify Breast Cancer Metastatic Colonization and Burden in the Lungs

Published on: December 19, 2019

11.2K
Identification and Characterization of Metastatic Factors by Gene Transfer into the Novel RIP-Tag; RIP-tva Murine Model
09:03

Identification and Characterization of Metastatic Factors by Gene Transfer into the Novel RIP-Tag; RIP-tva Murine Model

Published on: October 16, 2017

8.9K
Real-time Imaging of Heterotypic Platelet-neutrophil Interactions on the Activated Endothelium During Vascular Inflammation and Thrombus Formation in Live Mice
11:18

Real-time Imaging of Heterotypic Platelet-neutrophil Interactions on the Activated Endothelium During Vascular Inflammation and Thrombus Formation in Live Mice

Published on: April 2, 2013

15.9K

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Platelets were historically thought to have a fixed RNA content determined solely by megakaryocytes.
  • Emerging evidence shows external factors, notably cancer cells, can modify platelet RNA.
  • Platelets play active roles in cancer progression, including tumor growth and metastasis.

Purpose of the Study:

  • To review the mechanisms of RNA transfer between cancer cells and platelets.
  • To explore the potential of tumor-educated platelet RNA as biomarkers for cancer.
  • To discuss methods for analyzing platelet transcriptomic content.

Main Methods:

  • Literature review focusing on cancer cell-platelet interactions and RNA.
  • Analysis of studies investigating tumor-mediated platelet RNA alterations.
  • Examination of techniques for platelet RNA profiling.

Main Results:

  • Cancer cells actively influence platelet RNA composition through direct and indirect transfer.
  • Altered platelet RNA profiles in cancer patients represent a novel biomarker source.
  • Platelet RNA signatures offer potential for early cancer detection and treatment monitoring.

Conclusions:

  • Tumor-educated platelets provide a promising avenue for non-invasive cancer diagnostics.
  • Platelet RNA analysis, as a form of liquid biopsy, warrants further investigation.
  • Understanding cancer-platelet RNA dynamics is crucial for developing new biomarkers.