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UV-curable hyperbranched polyester sealant with tunable mechanical properties
Yan Jiao1,2, Lili Chu1,3, Miaomiao Zhu1,3
1Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital of Sun Yat-sen University-Guangzhou, China.
Journal of Biomaterials Applications
|May 4, 2021
Summary
This study introduces a new tunable wound sealant based on hyperbranched polyester (HBP). This UV-curable sealant offers adjustable mechanical properties and strong adhesion, outperforming current options for diverse wound healing applications.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Tissue Engineering
Background:
- Wound sealants require adaptable mechanical properties to match native tissues.
- Current sealants have limited tunability, restricting their application range.
- Developing versatile wound closure solutions is crucial for effective healing.
Purpose of the Study:
- To develop a novel UV-curable wound sealant with tunable mechanical properties.
- To enhance sealant adaptability for various wound types.
- To evaluate the performance and biocompatibility of the new sealant.
Main Methods:
- Synthesis of hyperbranched polyester (HBP)-based UV-curable sealant.
- Tuning mechanical properties via the degree of acrylation of HBPs.
- Assessing shear adhesive strength on porcine skin and elastic modulus via tensile testing.
- Evaluating biocompatibility through co-culturing with mouse mesenchymal stem cells (mMSCs).
Main Results:
- The sealant cured in 2 minutes under UV light.
- Achieved shear adhesive strength of 20-30 kPa on porcine skin, exceeding fibrin glue (~10 kPa).
- Exhibited tunable elastic modulus ranging from 27-54 MPa.
- Demonstrated no adverse effects on mMSC viability after 7 days of co-culturing.
Conclusions:
- The developed HBP-based sealant offers tunable mechanical properties and strong tissue adhesion.
- Its adjustable elastic modulus makes it suitable for wounds with varying tissue elasticity.
- This sealant represents a promising advancement for wound management and closure.
