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[Sjögren's syndrome in systemic scleroderma].

N G Guseva, M V Simonova, Z Z Kirtava

    Terapevticheskii Arkhiv
    |January 1, 1988
    PubMed
    Summary
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    Scleroderma systemic (SSD) patients show a higher prevalence of Sjogren's syndrome (SS), particularly in chronic cases. This association influences clinical manifestations and serological markers.

    Area of Science:

    • Rheumatology
    • Immunology
    • Dermatology

    Context:

    • Scleroderma systemic (SSD) is a complex autoimmune disease.
    • Sjogren's syndrome (SS) is another autoimmune disorder.
    • Investigating the co-occurrence of SSD and SS is crucial for understanding disease progression.

    Purpose:

    • To determine the prevalence of Sjogren's syndrome (SS) in patients with Scleroderma systemic (SSD).
    • To analyze the association between SSD and SS, including clinical and serological characteristics.
    • To characterize the specific manifestations of SS within the SSD patient cohort.

    Summary:

    • A study of 43 Scleroderma systemic (SSD) patients identified Sjogren's syndrome (SS) in various subgroups.
    • SS was more frequent in chronic SSD, correlating with sclerodactyly, telangiectasia, and calcinosis, but less with esophageal hypomobility and skin changes.

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  • Associated features included polyarthralgia, arthritis, Raynaud's syndrome, high RF titers, anti-Ro/La antibodies, and elevated immune complexes.

    • Impact:

    • Findings highlight that Sjogren's syndrome (SS) influences the clinical presentation of Scleroderma systemic (SSD).
    • The study identifies specific markers and symptoms indicative of co-existing SS in SSD patients.
    • Understanding this association aids in more accurate diagnosis and management of patients with overlapping autoimmune conditions.