Air Pollution, housing and respirfatory tract Infections in Children: NatIonal birth Cohort study (PICNIC): study
Graziella Favarato1, Tom Clemens2, Steven Cunningham3
1Population, Policy and Practice Research and Teaching Department, University College London Institute of Child Health, London, UK.
Insights
This study investigates how air pollution and poor housing impact childhood respiratory infections in the UK. Findings will help inform public health strategies to reduce hospital admissions for young children.
Area of Science:
- Environmental Epidemiology
- Pediatric Public Health
- Respiratory Medicine
Background:
- Respiratory tract infections (RTIs) are a leading cause of hospitalization for children under 5 in the UK.
- The specific contributions of ambient air pollution and adverse housing conditions to pediatric RTI admissions remain unclear in the UK context.
Purpose of the Study:
- To quantify the association between in-utero, infant, and childhood exposures to ambient air pollution and adverse housing conditions with the risk of RTI admissions in children under 5.
- To calculate population attributable fractions for air pollution and housing characteristics.
- To explore causal mechanisms linking housing and air pollution to infant RTI risk.
Main Methods:
- Utilizing national birth cohort data from England and Scotland, linked with civil registration, maternity, and hospital admission records.
- Enhancing cohorts with census data on housing and socioeconomic status, and small area-level air pollution and building characteristic data.
- Employing time-to-event analyses, population attributable fraction calculations, and causal mediation analyses.
Main Results:
- N/A - Study results are pending publication.
Conclusions:
- N/A - Study conclusions are pending publication.
Introduction:
Respiratory tract infections (RTIs) are the most common reason for hospital admission among children <5 years in the UK. The relative contribution of ambient air pollution exposure and adverse housing conditions to RTI admissions in young children is unclear and has not been assessed in a UK context.
Methods And Analysis:
The aim of the PICNIC study (Air Pollution, housing and respiratory tract Infections in Children: NatIonal birth Cohort Study) is to quantify the extent to which in-utero, infant and childhood exposures to ambient air pollution and adverse housing conditions are associated with risk of RTI admissions in children <5 years old. We will use national administrative data birth cohorts, including data from all children born in England in 2005-2014 and in Scotland in 1997-2020, created via linkage between civil registration, maternity and hospital admission data sets. We will further enhance these cohorts via linkage to census data on housing conditions and socioeconomic position and small area-level data on ambient air pollution and building characteristics. We will use time-to-event analyses to examine the association between air pollution, housing characteristics and the risk of RTI admissions in children, calculate population attributable fractions for ambient air pollution and housing characteristics, and use causal mediation analyses to explore the mechanisms through which housing and air pollution influence the risk of infant RTI admission.
Ethics, Expected Impact And Dissemination:
To date, we have obtained approval from six ethics and information governance committees in England and two in Scotland. Our results will inform parents, national and local governments, the National Health Service and voluntary sector organisations of the relative contribution of adverse housing conditions and air pollution to RTI admissions in young children. We will publish our results in open-access journals and present our results to the public via parent groups and social media and on the PICNIC website. Code and metadata will be published on GitHub.
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