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Fungaemia due to rare yeasts in paediatric intensive care units: A prospective study

Harsimran Kaur1, Shreya Singh1, Shivaprakash Mandya Rudramurthy1

  • 1Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Mycoses
|May 4, 2021
PubMed
Abstract

Insights

Rare yeasts like Wickerhamomyces anomalus and Candida utilis are increasingly causing fungaemia in children. This study highlights their epidemiology and resistance patterns, demanding urgent control measures.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Epidemiology

Background:

  • Fungaemia due to rare yeasts is an emerging concern in healthcare settings.
  • A systematic epidemiologic study was needed to understand this trend.

Purpose of the Study:

  • To investigate the epidemiological features of fungaemia caused by rare yeasts.
  • To describe the clinical characteristics of these infections in pediatric intensive care units (PICUs).

Main Methods:

  • Prospective observational study of yeast isolates from blood cultures in PICUs.
  • Molecular identification of yeasts, categorizing non-common Candida species as rare.
  • Antifungal susceptibility testing and comparison of clinical parameters between common and rare yeast fungaemia.

Main Results:

  • Rare yeasts accounted for 61.6% of fungaemia cases (127/207 isolates).
  • Wickerhamomyces anomalus (43.8%) and Candida utilis (40.8%) were predominant rare yeasts.
  • Significant associations found with surgical intervention and gastrointestinal disease; overall mortality was 65.3%.

Conclusions:

  • The rise of rare yeasts, particularly W. anomalus and C. utilis, in pediatric fungaemia requires immediate attention.
  • Urgent strategies are needed to control the spread of these resistant fungal infections.
Keywords:
MALDI-TOFantifungal susceptibilitycandidaemiafungaemiapaediatric intensive care unitsrare yeast

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