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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
Large disparities in 28-day case fatality by stroke subtype: data from a French stroke registry between 2008 and 2017
Victoria Gauthier1, Dominique Cottel1, Philippe Amouyel1
1Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, INSERM, CHU Lille, Institut Pasteur de Lille, Univ. Lille, Lille, France.
European Journal of Neurology
|May 4, 2021
Summary
Stroke case fatality remains high, particularly for hemorrhagic stroke. Prompt treatment in a neurology ward significantly improves survival rates by approximately 80%.
Area of Science:
- Neurology
- Public Health
- Epidemiology
Background:
- Stroke remains a leading cause of mortality and morbidity worldwide.
- Understanding stroke aetiology and associated factors is crucial for improving patient outcomes.
- Population-based registries are vital for epidemiological research on stroke.
Purpose of the Study:
- To assess 28-day stroke case fatality based on stroke aetiology.
- To identify factors associated with stroke mortality.
- To evaluate the impact of care setting on stroke outcomes.
Main Methods:
- Analysis of a population-based stroke registry in northern France (2008-2017).
- Inclusion of adult stroke events (age ≥35 years).
- Assessment of 28-day case fatality rates stratified by stroke aetiology and patient demographics.
Main Results:
- Overall 28-day case fatality was 48% for haemorrhagic stroke and 15% for ischaemic stroke.
- Higher case fatality in women with ischaemic stroke, which disappeared after age adjustment.
- Age, stroke severity, cardiovascular history, and nursing home residence were associated with poor prognosis; neurology ward care improved survival.
Conclusions:
- Post-stroke case fatality in northern France is notably high, especially for haemorrhagic stroke.
- Treatment in a neurology ward demonstrated a significant survival benefit of approximately 80%.
- Further research into stroke subtypes and risk factors is warranted to reduce mortality.
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