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Updated: Nov 7, 2025
An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment
Published on: July 28, 2012
[Bladder paraganglioma: Report of two cases and a literature review.]
Francisco J Pelegrín-Mateo1, Elena Seguí-Moya2, Marian Fernández-Cruz1
1Servicio de Oncología Médica. Hospital General Universitario de Elche. España.
Objective:
Description of two incidental cases of bladder paraganglioma in women and review of the published literature.
Methods:
A bibliographic search was carried out in Medline over the last 10 years according to the terms "urinary bladder" and "paraganglioma".
Results:
Bladder paraganglioma (BP) accounts for less than 0.06% of bladder tumors and 10% of all paragangliomas. It may be sporadic or associated with hereditary predisposition syndromes such as Hereditary Paraganglioma- Pheochromocytoma Syndrome. Due to its rarity, there are no recommendations for treatment and monitoring but, their risk of malignancy forces a long-term follow up. The study of germinal mutations through massive sequencing ruled out the association with a hereditary syndrome. Initial management included early reassessment by cystoscopy, transurethral bladder resection (TURB) and imaging.
Conclusions:
Bladder paragangliomas are rare tumors that can be associated to hereditary syndromes. Its treatment and follow - up must be based on a multidisciplinary approach.
