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Plasma lipid and apolipoprotein levels in children hereditarily predisposed to coronary heart disease
N Perova1, H Aingorn, V Metelskaya
1Institute of Preventive Cardiology, USSR Cardiology Research Center, Moscow.
Insights
Children with a family history of coronary heart disease exhibit altered plasma lipid profiles. These changes, including lower high-density lipoprotein cholesterol and higher triglycerides, indicate an increased risk for developing atherosclerosis.
Area of Science:
- Cardiovascular Science
- Lipid Metabolism
- Pediatric Cardiology
Background:
- Coronary atherosclerosis is a significant health concern with potential genetic predispositions.
- Understanding early-life risk factors for cardiovascular disease is crucial for prevention.
Purpose of the Study:
- To investigate plasma lipid and apoprotein levels in children with a paternal history of coronary heart disease.
- To compare these levels with children exhibiting blood pressure lability and a control group.
Main Methods:
- Measurement of plasma lipids, high-density lipoprotein cholesterol, triglycerides, and apoproteins A-I, A-II, and B.
- Comparison of lipid profiles across three groups: paternal coronary heart disease, blood pressure lability, and a random reference group.
Main Results:
- Children of fathers with coronary atherosclerosis showed lower high-density lipoprotein cholesterol and apoprotein A-I.
- Elevated low-density lipoprotein cholesterol, triglycerides, and apoprotein B were observed in the paternal coronary heart disease group.
- The most significant atherogenic lipoprotein profile changes were found in children with both paternal coronary heart disease and blood pressure lability.
Conclusions:
- Paternal coronary heart disease is associated with an atherogenic lipoprotein profile in offspring.
- Blood pressure lability exacerbates these lipid profile changes, suggesting a combined risk.
- Early identification of these lipid alterations may aid in cardiovascular disease risk assessment in children.
Abstract:
Plasma lipids and apoproteins A-I, A-II and B levels were measured in 125 children whose fathers had coronary atherosclerosis (paternal coronary heart disease group), in 172 children with blood pressure lability and in 154 children selected at random from a representative subsample (reference). The paternal coronary heart disease group had, compared with the reference group, lower levels of high density lipoprotein cholesterol and apoprotein A-I, higher levels of low density lipoprotein cholesterol, triglycerides and apoprotein B, and also a higher ratio of apoprotein B to apoprotein A-I. The paternal coronary heart disease group subjects with blood pressure lability had the most pronounced changes in the lipoprotein spectrum, which were similar to atherogenic changes in the lipoprotein profile, characteristic of patients with coronary atherosclerosis.