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Congenital hypothyroid goiter and amiodarone
D De Wolf1, J De Schepper, H Verhaaren
1Department of Pediatrics, RIA Academisch Ziekenhuis VUB, Brussels, Belgium.
Acta Paediatrica Scandinavica
|July 1, 1988
Summary
Maternal use of Amiodarone during pregnancy, an anti-arrhythmic drug, may lead to severe congenital hypothyroidism and goiter in newborns. This case highlights potential risks despite previous observations of no adverse fetal thyroid effects.
Area of Science:
- Cardiology
- Endocrinology
- Pharmacology
Background:
- Amiodarone is an anti-arrhythmic medication containing 39% iodine.
- Previous studies indicated no adverse effects on fetal thyroid function with maternal Amiodarone use during pregnancy.
Observation:
- A case study describes a newborn with severe congenital hypothyroidism and goiter.
- This condition was associated with maternal ingestion of 200 mg of Amiodarone daily starting from the 13th week of gestation.
Findings:
- No other environmental goiter causes or congenital thyroid disorders were identified in the infant.
- The study suggests a potential link between maternal Amiodarone intake and fetal thyroid dysfunction.
Implications:
- This case raises concerns about the safety of Amiodarone during pregnancy, particularly regarding fetal thyroid health.
- Further research is warranted to understand the risks and establish guidelines for Amiodarone use in pregnant patients.