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Baicalin-Aluminum Modulates the Broiler Gut Microbiome
Ling Guo1,2, Jing He1,2, Jiacheng Zhang1,2
1Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan, P.R. China.
DNA and Cell Biology
|May 4, 2021
Summary
Baicalin-aluminum significantly altered the gut microbiome in broilers, increasing beneficial bacteria like Lactobacillus. This suggests baicalin-aluminum could be a novel therapy for gut health in animals and humans.
Area of Science:
- Microbiology
- Animal Science
- Pharmacology
Background:
- Baicalin-aluminum is known to regulate the gut microbiome in piglets.
- Its effects on poultry gut microbiome composition and function are not well understood.
Purpose of the Study:
- To investigate the impact of baicalin-aluminum on the gut microbiome of poultry.
- To compare these effects with colistin sulfate administration.
Main Methods:
- Metagenomic sequencing was employed to analyze gut microbiome changes in broilers.
- Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed.
Main Results:
- Baicalin-aluminum administration led to significant alterations in broiler gut microbiome composition, with notable increases in species such as *Lactobacillus salivarius* and *Bacteroides uniformis* compared to colistin.
- Functional analysis revealed enrichment in metabolic processes, catalytic activity, cellular processes, ABC transporters, oxidative phosphorylation, and phosphotransferase systems.
Conclusions:
- Baicalin-aluminum effectively modifies the gut microbiome composition in broilers.
- These findings provide insights into baicalin-aluminum's functions and suggest its potential as a therapeutic agent for gut health.
