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Total and free testosterone in depressed men.

A J Levitt¹, R T Joffe

¹Department of Psychiatry, St. Michael's Hospital, Toronto, Canada.

Acta Psychiatrica Scandinavica

|March 1, 1988

Summary

Depressed males showed no significant differences in testosterone, estradiol, or cortisol levels compared to controls. However, total testosterone levels in depressed individuals were found to decrease with age.

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Area of Science:

Endocrinology
Neuroscience
Psychiatry

Background:

Hormonal imbalances, particularly in testosterone, estradiol, and cortisol, are frequently investigated in relation to major depressive disorder.
Previous research has yielded inconsistent findings regarding the role of these hormones in male depression.

Purpose of the Study:

To investigate differences in total and free testosterone, estradiol, and cortisol levels between depressed males and age-matched healthy controls.
To explore the relationship between these hormone levels, age, and depression severity.

Main Methods:

Serum levels of total testosterone, free testosterone, estradiol, and cortisol were measured.
Participants included 12 males diagnosed with depression and 12 age-matched healthy male volunteers.

Main Results:

No significant differences were observed in total testosterone, free testosterone, estradiol, or cortisol levels between the depressed group and the control group.
A significant negative correlation was found between total testosterone and age within the depressed group.
No significant correlation was found between total testosterone and the severity of depression.

Conclusions:

Circulating levels of testosterone, estradiol, and cortisol do not appear to differ between depressed males and healthy controls.
Age may influence total testosterone levels in depressed males, independent of depression severity.

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