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Phytochemicals in cancer and their effect on the PI3K/AKT-mediated cellular signalling

Olaf-Georg Issinger1, Barbara Guerra1

  • 1Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|May 4, 2021
PubMed

Insights

Natural phytochemicals show promise in targeting the PI3K/AKT pathway for cancer treatment. This review explores their potential in combating cancer by modulating key cellular activities and signalling pathways.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • Protein kinases are crucial enzymes regulating cellular functions like gene expression and metabolism.
  • Dysregulation of protein kinases is implicated in major diseases, especially cancer.
  • The PI3K/AKT signaling pathway is frequently altered in various cancers.

Purpose of the Study:

  • To review the potential of natural phytochemicals in cancer treatment.
  • To explore the connection between phytochemicals and targeting the PI3K/AKT pathway.
  • To summarize findings from cell culture and animal models.

Main Methods:

  • Literature review of studies on natural compounds and cancer.
  • Focus on phytochemicals targeting the PI3K/AKT pathway.
  • Analysis of data from in vitro and in vivo cancer models.

Main Results:

  • Natural compounds demonstrate efficacy in targeting the PI3K/AKT pathway.
  • Phytochemicals exhibit anti-cancer properties in cell cultures and animal studies.
  • Evidence suggests a therapeutic role for natural compounds in cancer.

Conclusions:

  • Natural phytochemicals represent a promising therapeutic strategy for cancer.
  • Targeting the PI3K/AKT pathway with natural compounds warrants further investigation.
  • Phytochemicals offer a potential avenue for novel cancer treatments.
Keywords:
CancerPI3K/AKT cell signallingPhytochemicals

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