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Updated: Nov 6, 2025

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
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SRC-3, a Steroid Receptor Coactivator: Implication in Cancer

Licen Li1,2, Chu-Xia Deng1,2, Qiang Chen1,2

  • 1Cancer Centre, Faculty of Health Sciences, University of Macau, Macau, China.

International Journal of Molecular Sciences
|May 5, 2021
PubMed

Insights

Steroid receptor coactivator-3 (SRC-3), a key cancer-promoting gene, regulates gene transcription. Understanding its role in carcinogenesis offers potential new avenues for cancer treatment strategies.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Steroid receptor coactivator-3 (SRC-3), also known as amplified in breast cancer 1 (AIB1), is part of the SRC family of proteins.
  • SRC-3 plays a crucial role in regulating the transcriptional activity of nuclear receptors and other transcription factors.
  • Beyond its physiological functions, SRC-3 is implicated as an oncogene in various cancers.

Purpose of the Study:

  • To review recent advancements in understanding SRC-3's role in cancer development (carcinogenesis).
  • To summarize the mechanisms through which SRC-3 contributes to cancer progression.
  • To identify potential therapeutic targets based on SRC-3's function in cancer.

Main Methods:

  • Literature review of studies on SRC-3 and cancer.
  • Analysis of SRC-3's molecular functions and interactions.
  • Synthesis of information regarding SRC-3's involvement in different cancer types.

Main Results:

  • SRC-3 is a significant factor in promoting multiple facets of cancer.
  • Its function as an oncogene is mediated through the regulation of diverse transcriptional pathways.
  • Recent research highlights specific modes of action in carcinogenesis.

Conclusions:

  • SRC-3 is a critical player in cancer initiation and progression.
  • Elucidating SRC-3's mechanisms provides valuable insights for developing targeted cancer therapies.
  • Targeting SRC-3 may offer a promising strategy for future cancer treatment.
Keywords:
AIB1SRC-3cancercoactivator

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