Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Co-activators and Co-repressors

Co-activators and Co-repressors

Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...

Co-activators and Co-repressors

Co-activators and Co-repressors

Transducer Mechanism: Nuclear Receptors

Transducer Mechanism: Nuclear Receptors

Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:

mTOR Signaling and Cancer Progression

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Nicotinamide-derived tumor-targeting carbon dots for Cancer Photothermal therapy.

Journal of colloid and interface science·2026

Same author

Recent progresses in cancer multidrug resistance and therapeutic options associated with protein damage response.

Protein & cell·2026

Same author

Low dose radiation induces new protein synthesis that promotes cancer radiotherapy resistance.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy·2026

Same author

GNL3 Orchestrates AR Transcriptional Programs to Drive Castration-Resistant Prostate Cancer and Immune Evasion.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same author

DUSP22 dephosphorylates LGALS1 to enhance T cell-driven antitumor immunity.

Journal for immunotherapy of cancer·2026

Same author

Tumor cell intrinsic dsRNA innate immune response triggered by PARP inhibitor is compromised in BRCA1-deficient breast cancer by repressing IRF3.

Protein & cell·2026

Search research articles

Related Experiment Video

Updated: Nov 6, 2025

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists

Published on: November 15, 2013

SRC-3, a Steroid Receptor Coactivator: Implication in Cancer.

Licen Li^1,2, Chu-Xia Deng^1,2, Qiang Chen^1,2

¹Cancer Centre, Faculty of Health Sciences, University of Macau, Macau, China.

International Journal of Molecular Sciences

|May 5, 2021

Summary

Steroid receptor coactivator-3 (SRC-3), a key cancer-promoting gene, regulates gene transcription. Understanding its role in carcinogenesis offers potential new avenues for cancer treatment strategies.

Keywords:

AIB1 SRC-3 cancer coactivator

More Related Videos

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment

Published on: June 9, 2023

Merging Absolute and Relative Quantitative PCR Data to Quantify STAT3 Splice Variant Transcripts

Merging Absolute and Relative Quantitative PCR Data to Quantify STAT3 Splice Variant Transcripts

Published on: October 9, 2016

Related Experiment Videos

Last Updated: Nov 6, 2025

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists

Published on: November 15, 2013

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment

Published on: June 9, 2023

Merging Absolute and Relative Quantitative PCR Data to Quantify STAT3 Splice Variant Transcripts

Merging Absolute and Relative Quantitative PCR Data to Quantify STAT3 Splice Variant Transcripts

Published on: October 9, 2016

Area of Science:

Molecular Biology
Oncology
Genetics

Background:

Steroid receptor coactivator-3 (SRC-3), also known as amplified in breast cancer 1 (AIB1), is part of the SRC family of proteins.
SRC-3 plays a crucial role in regulating the transcriptional activity of nuclear receptors and other transcription factors.
Beyond its physiological functions, SRC-3 is implicated as an oncogene in various cancers.

Purpose of the Study:

To review recent advancements in understanding SRC-3's role in cancer development (carcinogenesis).
To summarize the mechanisms through which SRC-3 contributes to cancer progression.
To identify potential therapeutic targets based on SRC-3's function in cancer.

Main Methods:

Literature review of studies on SRC-3 and cancer.
Analysis of SRC-3's molecular functions and interactions.
Synthesis of information regarding SRC-3's involvement in different cancer types.

Main Results:

SRC-3 is a significant factor in promoting multiple facets of cancer.
Its function as an oncogene is mediated through the regulation of diverse transcriptional pathways.
Recent research highlights specific modes of action in carcinogenesis.

Conclusions:

SRC-3 is a critical player in cancer initiation and progression.
Elucidating SRC-3's mechanisms provides valuable insights for developing targeted cancer therapies.
Targeting SRC-3 may offer a promising strategy for future cancer treatment.