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Updated: Nov 6, 2025

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer
07:59

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer

Published on: September 8, 2023

1.4K

Genomic Characterization of Concurrent Alterations in Non-Small Cell Lung Cancer (NSCLC) Harboring Actionable

Antonio Passaro1, Ilaria Attili1, Alessandra Rappa2

  • 1Division of Thoracic Oncology, IEO, European Institute of Oncology, IRCCS, 20141 Milan, Italy.

Cancers
|May 5, 2021
PubMed

Insights

Concurrent genomic alterations in non-small cell lung cancer (NSCLC) are common, with distinct patterns observed in oncogene-addicted tumors. These co-alterations may impact prognosis and treatment strategies.

Area of Science:

  • Oncology
  • Genomics
  • Molecular Biology

Background:

  • Non-small cell lung cancer (NSCLC) treatment increasingly targets specific genomic alterations.
  • Comprehensive genomic profiling reveals concurrent genetic changes in NSCLC, but their patterns in oncogene-addicted cases are less understood.

Purpose of the Study:

  • To investigate the incidence and distribution of concurrent genomic alterations in oncogene-addicted NSCLC.
  • To identify patterns of co-occurring aberrations using next-generation sequencing (NGS).

Main Methods:

  • Retrospective analysis of genomic data from advanced NSCLC patients treated with a broad NGS panel.
  • Categorization of tumors based on actionable gene alterations and concurrent aberrations.

Main Results:

  • 309 actionable alterations were found in 284 patients; 8% of tumors had concurrent actionable gene alterations.
  • 82.8% of concurrent alterations involved pathogenic variants or copy number variations (CNVs).
  • Significant differences in co-alteration patterns (TP53, STK11, cyclins, RTKs) were noted across actionable gene groups.

Conclusions:

  • NGS analysis reveals distinct co-alteration profiles in oncogene-addicted NSCLC.
  • Further research is required to determine the prognostic and therapeutic significance of these concurrent genomic alterations.
Keywords:
ALKBRAFEGFRERBB2KRASMETRETco-mutationnext generation sequencingpredictive biomarker

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