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Updated: Nov 6, 2025

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
04:41

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

Published on: July 3, 2018

8.4K

MicroRNAs in Acute ST Elevation Myocardial Infarction-A New Tool for Diagnosis and Prognosis: Therapeutic

Alina Ioana Scărlătescu1,2, Miruna Mihaela Micheu2, Nicoleta-Monica Popa-Fotea1,2

  • 1Department of Cardiology, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.

International Journal of Molecular Sciences
|May 5, 2021
PubMed

Insights

microRNAs (miRNAs) show promise for diagnosing and predicting outcomes in ST-elevation myocardial infarction (STEMI). These small molecules offer potential as early diagnostic markers and therapeutic targets for heart attack patients.

Area of Science:

  • Cardiology
  • Molecular Biology
  • Genetics

Background:

  • ST-elevation myocardial infarction (STEMI) remains a primary cause of death globally.
  • Early diagnosis is crucial for improving STEMI patient prognosis.
  • microRNAs (miRNAs) are implicated in cardiovascular disease pathophysiology.

Purpose of the Study:

  • To review the current understanding of miRNAs in STEMI.
  • To explore the role of miRNAs as diagnostic markers for myocardial infarction.
  • To summarize the prognostic and therapeutic potential of miRNAs in STEMI.

Main Methods:

  • Literature review of studies on miRNAs and STEMI.
  • Analysis of circulating miRNA levels in acute coronary syndromes (ACS).
  • Evaluation of miRNA function in gene regulation relevant to cardiac damage.

Main Results:

  • Elevated circulating miRNA levels indicate cardiac damage in ACS.
  • miRNAs serve as promising biomarkers for early myocardial infarction diagnosis.
  • miRNAs possess prognostic value and therapeutic potential in STEMI.

Conclusions:

  • miRNAs are significant in cardiovascular disease, particularly STEMI.
  • Circulating miRNAs offer a valuable tool for early STEMI diagnosis and prognosis.
  • Targeting miRNAs presents a promising therapeutic strategy for STEMI management.

Keywords:
STEMIbiomarkersmiRNA

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