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Basic and Preclinical Research for Personalized Medicine.

Wanda Lattanzi1,2, Cristian Ripoli1,3, Viviana Greco1,4

  • 1Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.

Journal of Personalized Medicine
|May 5, 2021
PubMed
Summary
This summary is machine-generated.

Basic and preclinical research, including stem cells, omics technologies, and neuroscience, drives personalized medicine. These advances bridge the gap from lab discoveries to patient treatments, improving care.

Keywords:
genomicsinduced pluripotent stem cellsmesenchymal stem cellsneurosciencepersonalized medicineproteogenomicsproteomicsstem cells

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Area of Science:

  • Biomedical Research
  • Translational Science

Background:

  • Personalized medicine advances are built upon extensive basic and preclinical research.
  • Genomics and omics technologies have significantly enhanced understanding of the functional genome and its role in patient phenotypes and disorders.
  • Biotechnological progress facilitates the discovery of disease mechanisms and the development of tailored treatments.

Purpose of the Study:

  • To review key scientific milestones in basic and preclinical research contributing to personalized medicine.
  • To highlight the role of stem cells, omics technologies, and neuroscience in this revolution.
  • To discuss the translation of research from the laboratory to clinical application (bench-to-bed).

Main Methods:

  • Review of scientific literature and research progress.
  • Focus on advancements in stem cell research, omics technologies, and neuroscience.
  • Analysis of how these fields contribute to personalized patient care.

Main Results:

  • Integrated profiling data from research fuels personalized medicine applications.
  • Omics technologies provide deeper insights into patient phenotypes and disorders.
  • Stem cell research offers tools for regenerative medicine, while neuroscience aids in early disease detection.

Conclusions:

  • Basic and preclinical research are fundamental to the personalized medicine revolution.
  • Stem cells, omics, and neuroscience are pivotal areas bridging research and clinical practice.
  • Continued progress in these fields is essential for advancing patient-centered care and cures.