Related Experiment Video

Updated: Nov 6, 2025

Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases
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Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases

Published on: October 10, 2020

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Glutathione S-Transferases in Cancer

Rahul Raj Singh1, Katie M Reindl1

  • 1Department of Biological Sciences, North Dakota State University, Fargo, ND 58108, USA.

Antioxidants (Basel, Switzerland)
|May 5, 2021
PubMed

Insights

Glutathione S-transferases (GST) are key antioxidant enzymes implicated in cancer development and drug resistance. This review explores GSTs

Area of Science:

  • Biochemistry and Molecular Biology
  • Oncology
  • Pharmacology

Background:

  • Glutathione S-transferases (GSTs) are a family of crucial antioxidant enzymes in humans.
  • These enzymes regulate stress-induced signaling pathways and are often overactive in cancers.
  • GSTs play complex roles in tumorigenesis, including promoting cell survival, proliferation, and drug resistance.

Purpose of the Study:

  • To review recent findings on GST protein biology in cancer.
  • To discuss the role of GSTs in cancer development and chemoresistance.
  • To highlight the development of GST inhibitors for cancer therapy.

Main Methods:

  • Literature review of recent studies on GSTs in cancer.
  • Analysis of structural and pharmacological data for GST inhibitors.
  • Synthesis of information on GSTs' roles in tumorigenesis and drug resistance.

Main Results:

  • GST proteins are actively involved in key tumorigenic processes.
  • Overactive GSTs are frequently observed in various human cancers.
  • Numerous GST inhibitors have been identified and advanced to clinical trials.

Conclusions:

  • GSTs are multifaceted proteins with significant roles in cancer progression.
  • Targeting GSTs with inhibitors presents a promising therapeutic strategy for cancer treatment.
  • Further research into GST biology and inhibitor development is warranted.
Keywords:
GST inhibitorsGlutathione S-transferases (GSTs)JNKantioxidantsapoptosiscancer-cell signalingchemoresistanceglutathionylationmetabolismoxidative stresspatient survivalxenobiotic compounds

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