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Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells
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Cardiac Glycosides as Immune System Modulators.
Jan Škubník1, Vladimíra Pavlíčková1, Silvie Rimpelová1
1Department of Biochemistry and Microbiology, University of Chemistry and Technology Prague, Technická 3, 166 28 Prague 6, Czech Republic.
Biomolecules
|May 5, 2021
Summary
Cardiac glycosides (CGs), known for heart conditions, show promise as anticancer and immunomodulatory agents. Their ability to affect immune cells and pathways suggests potential for treating autoimmune and inflammatory diseases.
Area of Science:
- Pharmacology
- Immunology
- Oncology
Background:
- Cardiac glycosides (CGs) are natural compounds historically used for cardiac diseases.
- CGs inhibit Na+/K+-ATPase (NKA) to modulate heart contractility.
- Emerging research reveals broader therapeutic potential beyond cardiovascular applications.
Purpose of the Study:
- To review the immunomodulatory properties of cardiac glycosides.
- To highlight the potential clinical applications of CGs in autoimmune and inflammatory diseases.
Main Methods:
- Literature review of studies on CGs' effects on immune cells and pathways.
- Analysis of CGs' mechanisms in cancer and immune modulation.
- Synthesis of current knowledge on CGs' therapeutic potential.
Main Results:
- CGs exhibit antiproliferative effects via NKA signalosomes, inducing immunogenic cell death.
- CGs modulate T-helper cell activity and NF-κB signaling.
- CGs influence cytokine/chemokine levels and immune cell ratios.
Conclusions:
- CGs possess significant immunomodulatory effects.
- CGs demonstrate potential for treating autoimmune and inflammatory conditions.
- Further research into CGs' clinical applications is warranted.
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