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Prevalence of paraprotein interference in three clinical chemistry analytes in a routine biochemistry laboratory

Lindsay Graham1, Dinesh Talwar1, Neil R Syme1

  • 1Clinical Biochemistry, Glasgow Royal Infirmary, Glasgow, UK.

Annals of Clinical Biochemistry
|May 5, 2021
PubMed
Abstract

No abstract available in PubMed .

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Inductively coupled plasma–mass spectrometry (ICP–MS) is a highly selective and sensitive technique for accurate elemental analysis. Though the analysis of ICP–MS mass spectra is comparatively straightforward, it is affected by spectroscopic and non-spectroscopic interferences. Spectroscopic interferences arise when the plasma contains ionic species with an m/z value the same as the analyte ion. Spectroscopic interference can be categorized as isobaric, polyatomic ions, and...
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