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Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel FilmWound Healing
Published on: December 13, 2024
971
Aloe Vera extract-based composite nanofibers for wound dressing applications
Raul Barbosa1, Alexa Villarreal1, Cristobal Rodriguez2
1Department of Mechanical Engineering, University of Texas Rio Grande Valley, Edinburg, TX 78539, USA.
Summary
New biocompatible nanofibers from Aloe vera, pullulan, and chitosan show promise for wound dressings. These materials offer excellent water absorption and antibacterial properties, promoting healing.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Polymer Science
Background:
- Advanced wound dressings are crucial for effective healing and infection prevention.
- Natural polymers offer biocompatible and biodegradable alternatives for biomedical applications.
- Composite nanofibers provide a high surface area and porous structure beneficial for wound management.
Purpose of the Study:
- To develop and characterize natural, biocompatible, and biodegradable composite nanofibers.
- To investigate the effect of Aloe vera extract loading on nanofiber properties.
- To evaluate the potential of these nanofibers for wound dressing applications.
Main Methods:
- Forcespinning® technology was used to fabricate composite nanofibers.
- Materials characterization included scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA).
- Antibacterial activity and cell attachment/growth were assessed.
Main Results:
- Successfully produced composite nanofibers containing Aloe vera extract, pullulan, and chitosan.
- Nanofibers demonstrated good water absorption and synergistic antibacterial activity against Escherichia coli.
- Promoted cell attachment and growth, indicating good biocompatibility.
- Porous structure and high surface area were confirmed.
Conclusions:
- The developed Aloe vera-based composite nanofibers are suitable for wound dressing applications.
- These nanofibers possess excellent wound healing properties, including fluid absorption and infection control.
- The materials offer a promising, natural alternative for advanced wound care solutions.
