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In Vivo Immunofluorescence Localization for Assessment of Therapeutic and Diagnostic Antibody Biodistribution in Cancer Research
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In Vivo Immunofluorescence Localization for Assessment of Therapeutic and Diagnostic Antibody Biodistribution in Cancer Research

Published on: September 16, 2019

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Antibody-based cancer therapy

Rebecca S Goydel1, Christoph Rader2

  • 1Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, USA.

Oncogene
|May 5, 2021
PubMed

Insights

Antibody therapeutics, with nearly 100 Food and Drug Administration approvals, are vital in oncology. This review explores antibody-based cancer therapies, categorized by their mechanisms, and their evolving landscape.

Area of Science:

  • Biotechnology
  • Immunology
  • Oncology

Background:

  • Antibody therapeutics have become major pharmaceuticals over 25 years.
  • Nearly 100 Food and Drug Administration approvals and $100 billion in global sales highlight their success.
  • Approximately 50% of antibody therapeutics are utilized in cancer treatment.

Purpose of the Study:

  • To provide an overview of antibody-based cancer therapies.
  • To discuss the mechanisms of action for antibody-based cancer therapies.
  • To offer an outlook on the future of antibody-based cancer therapy.

Main Methods:

  • Review of existing literature on antibody therapeutics in oncology.
  • Categorization of antibody-based cancer therapies based on mechanisms of action.
  • Analysis of the structural properties of antibody molecules.

Main Results:

  • Antibody-based cancer therapies are categorized into three main types: natural properties, T-cell engagement, and payload delivery.
  • The efficacy of these therapies is based on the stable and modular architecture of antibodies.
  • The field of antibody-based cancer therapy is rapidly evolving.

Conclusions:

  • Antibody therapeutics represent a significant advancement in cancer treatment.
  • The diverse mechanisms of action offer various therapeutic strategies.
  • The modular nature of antibodies supports ongoing innovation and future development in oncology.

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