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Updated: Nov 6, 2025

Large-Scale SARS-CoV-2 Testing Utilizing Saliva and Transposition Sample Pooling

Large-Scale SARS-CoV-2 Testing Utilizing Saliva and Transposition Sample Pooling

Published on: June 23, 2022

Testing at scale during the COVID-19 pandemic.

Tim R Mercer^1,2,3, Marc Salit^4,5

¹Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, QLD, Australia. t.mercer@uq.edu.au.

Nature Reviews. Genetics

|May 5, 2021

Summary

The COVID-19 pandemic spurred massive innovation in public health testing, including genomic surveillance and contact tracing. This review examines the evolution and impact of large-scale testing strategies for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

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Area of Science:

Virology
Epidemiology
Public Health

Background:

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome's release enabled rapid diagnostic test development.
The COVID-19 pandemic initiated the largest global testing program in history.

Purpose of the Study:

To describe the evolving role of testing during the COVID-19 pandemic.
To examine innovations in testing strategies, technologies, and concepts for public health.
To consider diagnostic and epidemiological principles of population-scale testing.

Main Methods:

Genomic surveillance to track SARS-CoV-2 transmission globally.
Contact tracing to contain disease outbreaks.
Environmental testing for SARS-CoV-2 presence.
Review of high-throughput and point-of-care testing technologies.

Main Results:

Testing evolved to include genomic surveillance, contact tracing, and environmental monitoring.
Population-scale testing became crucial for identifying and isolating asymptomatic individuals.
Technological advancements enabled massive-scale testing feasibility.

Conclusions:

The COVID-19 pandemic significantly advanced public health testing capabilities.
Large-scale testing, including for asymptomatic cases, is essential for managing widespread transmission.
Innovations in diagnostic and epidemiological approaches are key to future pandemic preparedness.